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Creative Biolabs Introduces Comprehensive Bispecific Antibody Analysis Services

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Creative Biolabs Introduces Comprehensive Bispecific Antibody Analysis Services

February 28
19:36 2019

New York – February 28, 2019 – Creative Biolabs, an antibody provider specialized in bispecific antibodies, now introduces a comprehensive list of necessary bispecific antibody analysis services, including biochemistry characterization, functional analysis as well as PK/PD analysis for the different stages of BsAb development.

Bispecific antibodies (BsAbs) recognize two different epitopes, based on the coupling of two antigen-recognizing elements into a single construct, which have reached outstanding clinical results. To develop BsAbs for treating diseases, it is critically important to perform comprehensive BsAb analysis to ensure their quality and function.

1. Biochemical characterization

Biochemical characterization plays an important role in the BsAb development. There are mainly three stages in biochemical characterization as follows:

– Purity Measurement: the sodium-dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis, the liquid chromatography-mass spectrometry (LC-MS) analysis and partial-filling affinity capillary electrophoresis (PFACE) analysis.

– Molecular Weight/Mass Measurement: size-exclusion chromatography multi-angle light scattering (SEC-MALS), electrospray ionization mass spectrometry (ESI-MS) and electrospray ionization time-of-flight (ESI-TOF).

– Molecular Structure Analysis: nuclear magnetic resonance (NMR) spectroscopy, small-angle X-ray scattering (SAXS), and molecular docking analysis.

2. Functional analysis

Creative Biolabs offers a number of BsAb functional analysis services, such as target binding affinity measurement, ADCC assay, CDC assay, and ADCP assay. In addition, a reporter-gene assay is developed to enable fast and more reliable measurement of ADCP for BsAbs.

3. Pharmacokinetic and pharmacodynamic (PK/PD) analysis

Usually, antibody drugs display much more complex PK/PD properties than those common small-molecule drugs. For the development of therapeutic antibodies, absorption analysis, distribution analysis, metabolism and elimination analysis are all available in Creative Biolabs.

“Through consistent efforts over the decade of all staff and scientists in Creative Biolabs, such a complete technology platform has been established to cover all clients’ specific needs in BsAb development process. Besides, in order to measure the efficacy and safety of the drug candidates during drug development, a range of models, ranging from test tube experiments to cell cultures, animals, and healthy human subjects, are utilized at different stages. A variety of models are available in Creative Biolabs for BsAb development,” added by the chief scientist occupied in Creative Biolabs.

More information on bispecific antibody development can be found at https://www.creative-biolabs.com/bsab.

About Creative Biolabs

Creative Biolabs was established in 2004 by scientists who are dedicated to conquering of cancer. Over the past 10 years, Creative Biolabs has grown into a recognized world leader in antibody (rAb) discovery, engineering, production, and analysis. Standing on the shoulder of a giant, the bispecific antibody (BsAb) team has a collective of experienced scientists committed to providing high-quality services to customers all over the world. Now, with the cutting-edge platforms and methods (quadroma development, chemical conjugation, and genetic engineering), a comprehensive list of bispecific antibody products is available to customers in academia and industry fields.

Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-619-7922
Address:45-1 Ramsey Road
City: Shirley
State: New York
Country: United States
Website: www.creative-biolabs.com/bsab